I think you're onto something. The mechanics only know what exhaust and model the tunes are for. They've probably never seen the actual fuel tables. I just looked at F1, the main fuel table for cylinder 1. 20226 is for the standard R3 with aftermarket exhaust and no cat. It is fatter at high RPM and TP than 20227. 20219 is the same as 20226 except it's for the Classic.
However, 20222, which is for stock exhaust on the standard R3, has the same F1 table as 20226. There are other differences - in the secondaries and ignition tables.
Anyone can download the Tuneboy program and all the tunes for free.