That's good news for you. We have in Washington but few in states like crazy California.
No you don't need to change the tune. I get better fuel economy when I put it in my bikes.
There is much information available on the Internet about ethanol fuel, why it came to be mandated, and the damage it can cause, primarily in carburated bikes, outboard motors, small utility engines, generators etc., that have rubber hoses and components in the fuel system.
The below web site lists the sources for non-ethanol fuel throughout the US and Canada. It shows quite a few in Maine.
I dont think it runs any different, but there are many articles related to corrosion in the fuel system etc related to ethanol, plus playing havok on soft goods like seals and gaskets. Its hard to find fuel near me that doesn't have at least 10% ethanol.