I ran the MC 2s in the 130/90-16 F and 180/65-16 R on my 09 Nomad and would get 20-25,000 miles out of the front and the rear. This bike is similar in weight to the R3T. I had 133,421 miles on my Nomad when I got rid of it for my 14 R3T with 2,700 miles on it. I had Avons put on because the original tires were 4 years old and I had 1,200 miles to go to get it home. I am looking forward to seeing what kind of mileage I get out of the Avons. I am running them 38F/44R per Avon's recommendation on their website. So far I have put over 4,200 miles on them in the two months I have had the bike.
One thing I noticed about the MC2s on my Nomad, as the front tire wore down, it would develop a wobble. When the tire was new, I could take my hands off the bars and the bike would track straight. However, as it wore down, the front would wobble if I took my hands off the bars. With my hands on the bars, there were no problems and the bike handled fine. I had enough Ride-On tire sealant in it to help balancing as well as having the tire balanced when it was installed. I could not see evidence of cupping. I am a daily rider and keep up on my tire pressures. This wobble happened with each front tire I had as it wore down. Other than that, these are good tires in both dry and wet conditions.