Make sure that the drivers files are in the same File as the TuneECU files. I have to open the drivers first and then one Tune ECU, connect the cable to bike and PC, open Tune ECU, go to ECU on the top and hit Connect, if connected, disconnect and reconnect. Go to Options, interface, serial, USB, switch bike on without hitting the starter and the red light on the right bottom should start blinking yellow then green and you are ready. For some reason the drivers and the Tune ECU programs have to be opened independently.