Unfortunately even though I live in Missouri, I'm not much help. I'm way up in northwest Missouri, have rode thru south Missouri couple times on way to Eureka springs, Arkansas and the pig trail. Missouri has a ton of paved roads, trick is finding a scenic route that also has good pavement. Some are not maintained at all. And some end in gravel with no warning. Probably best to use one of those apps that tell you scenic routes and road construction and stuff. There is a bunch of forests, and lakes, and caves, and state parks. Should be a fun trip.