I know of at least one other rider running asymmetrical tread and not aware of any problems with it. He's a very experienced rider so I presume he knows what he's doing. I wouldn't do it though.
Hanso has a 245 D/S on his and shows no signs of having handling issues....
If you don't like the D/S maybe give the Bridgstone Exedra Max a go. I found it handles better than Avon and gives at least 50% better mileage (100% better than Mtz). It is a 240/55 so has higher profile but I, and just about everyone else using them, see that as big plus.