The R3, even high comp, isn't terribly knock limited. You can advance it so far you have issues, as you can with any motor, but, reaching optimal timing isn't difficult. If you think about the missing timing, its nearly 4 full points of comp higher than stock and only a handful of degrees need be taken out. Dynamic CR stock is a little under 8:1, dynamic on my motor is right around 9:1.
I'm sure there's something be gained on a built motor, I simply don't think it'll be what force induced cars see. They have knock sensors etc that aggressively pull back timing after a single event to prevent further events, which is why they run so much better on E85, because they're heavily knock limited. On the R3 if you had a single knock event, you'd never know it, nor would the ECU, and it would just power right through dumb as a box of rocks, the nature of the stock ECU. Since it's so dumb, I've taken some measures, running the 7 range plugs, keeping it a little fat in AFRs (high 12s), and running MMT octane booster when tuning (the booster that actually works to shift full points, not fractions of a point).
To fully get the most bang out of E-85, you would need to adjust the build in the motor to need it, which would be a monster of a bike haha.
Below is a known map, that makes pretty much all the power the stock configuration has to offer:
This is my map, which, I know doesn't knock on 92 octane and makes good smooth power: