None have been fried that I am aware of. Turn everything off, including the computer. Reboot the computer and connect it to the bike as per the instructions. Make sure that the cable is plugged into the same USB port on the computer that you used when you read the tune off the bike. (I know that it should work in any USB port, but for some reason that is not always the case.) Make sure that the bike battery is FULLY charged. If you have left the ignition on for 20 hours then the battery won't be charged, and you may have caused some problems with other things. When you have done all of that, it should communicate. You may need to do a "recovery from failed download" as well.