It depends on the tire. I ran a 205 60 profile runflat with no issues. I went to a Triple Tread Goodyear 205 65 16 and with me 285lbs, my wife 190lbs, and the bike loaded 75lbs, it would rub when we hit bumps. But understand, the triple tread at a 65 profile was actually 8" wide. It rubbed up towards the front of fender where the tail light wires came through the fender. If you stay less than 8" in width, you should be fine.